Issue: Herbalism and Herbs
Author: University of Córdoba
Published: 2024/10/17
Post type: Experimental study – Peer Reviewed: Yeah
Content: Summary – Definition – Introduction – Main article – Related topics
Synopsis: A study evaluates the beneficial effects of fermented black garlic extract on prostate cancer. Prostate cancer is the third cause of death from cancer in men in Spain. It can progress from benign hyperplasia (prostate growth) to localized prostate cancer or metastatic castration-resistant cancer, for which few medications are available. We tested the extract on different human prostate cancer cell models and found that it was able to reduce several parameters of tumor aggressiveness, including cell proliferation. We also found that it did not affect normal prostate cells. Everything indicates that this compound could be a very good option to avoid some of the adverse events that occur in patients who are going to progress to a more complex and aggressive stage of prostate cancer.
Why it is important: This article on black garlic and prostate cancer highlights a possible natural remedy for a widespread health problem. Researchers at the University of Nottingham have found that aged black garlic extract shows promise in slowing the growth of prostate cancer cells. This finding is particularly noteworthy since prostate cancer is one of the most common cancers in men and the study suggests a possible dietary intervention that could complement existing treatments. The research also demonstrates how traditional foods, when processed differently, can generate new health benefits, potentially opening avenues for further exploration in cancer prevention and treatment strategies. Disabled world.
Introduction
The protective effects of an aged black garlic water extract on the prostate
A team from the University of Córdoba and IMIBIC tests the protective effect of a fermented black garlic extract against inflammation and the progression of prostate cancer in a study carried out in human prostate cancer cell models in the laboratory.
Main article
Prostate cancer is the third cause of death from cancer in men in Spain. It can progress from benign hyperplasia (prostate growth) to localized prostate cancer or metastatic castration-resistant cancer, for which few medications are available.
The OncObesity and Metabolism group, formed by research staff from the University of Córdoba and the Maimónides Biomedical Research Institute (IMIBIC) of the city, studies the antitumor effects of beneficial natural compounds that can be included in the diet and act against different types of cancer. .
Researchers Raúl M. Luque, María Loreta Libero and Antonio J. Montero recently studied the beneficial effects of a fermented black garlic extract on prostate cancer cells. Taking into account a previous experiment in mice in which the extract was found to have anti-inflammatory characteristics, and considering the important role of inflammation in prostate cancer, they decided to evaluate its effect in cellular models of human prostate cancer.
“We tested the extract in different human prostate cancer cell models and verified that it was capable of reducing various parameters of tumor aggressiveness, including cell proliferation,” explains researcher Antonio Montero. “We also found that it did not affect normal prostate cells.”
In this way, he indicated, this compound could be administered as a dietary supplement without potentially negative effects on healthy prostate cells.
The group’s principal investigator, Raúl Luque, explained how, after demonstrating the anticancer effects of the compound, “we wanted to know which molecular pathways were affected by the use of the compound and we were able to verify which key signaling pathways in cancer were altered, including those related to inflammation. The treatment decreases the inflammatory environment that can be seen in this type of cancer. The extract was more effective and able to produce more changes when the cells were in a pro-inflammatory environment. Local inflammation could be related to the aggressiveness of the cancer, and the fact that this extract acts on it could be due to its reduced aggressiveness after treatment with the extract.
According to Luque:
“Everything indicates that this compound could be a very good option to avoid some of the adverse events that occur in patients who are going to progress to a more complex and aggressive stage of prostate cancer.”
To know the preventive effect of this compound, the next steps would involve conducting a pilot study in people with a family history of prostate cancer, or continuing with a clinical study in patients who already suffer from it, administering this compound to evaluate whether the cancer progresses. It can be slowed down or stopped.
Reference
Libero, ML; Montero-Hidalgo, AJ; Recinella, L.; Luque, RM; Generali, D.; Acquaviva, A.; Orlando, G.; Ferrante, C.; Menghini, L.; Di Simone, South Carolina; et al. The protective effects of an aged black garlic water extract on the prostate. Nutrients 2024, 16, 3025.
Attribution/Source(s):
This peer-reviewed publication was selected for publication by the editors of Disabled World due to its important relevance to the disability community. Originally written by University of Córdobaand published on 10/17/2024, content may have been edited for style, clarity, or brevity. For more details or clarifications, University of Córdoba You can contact us at uco.es/internacional/extranjeros/en/. NOTE: Disabled World does not provide any warranty or endorsement related to this item.
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Cite this page (APA): University of Córdoba. (2024, October 17). Black garlic extract shows promise against prostate cancer. Disabled world. Retrieved October 17, 2024 from www.disabled-world.com/medical/alternative/herbal/black-garlic-prostate.php
Permanent link: Black garlic extract shows promise against prostate cancer: A study evaluates the beneficial effects of fermented black garlic extract on prostate cancer.
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